Parametrizing alternating current stimulation for neuromodulation.

ABSTRACT: The clinical use of alternating current stimulation (ACS) has been confounded by heterogeneity in patient responses. Optimization of this treatment requires understanding the dependence of neuronal responses on ACS parameters. We sought to characterize neuronal responses across varying ACS frequencies and amplitudes and assess the extent to which changes in neuronal activity persist beyond the cessation of the stimulation, thereby informing ACS optimization pathways and evaluating the potential for sustained neuromodulation. We delivered subcutaneous ACS while recording intracortical electrophysiological activity in adult rats. We applied ACS for 1 or 20 minutes and analyzed ensuing spiking activity, power spectra, and low-frequency to high-frequency phase-amplitude coupling (LF-HF PAC). B

SUBMITTER: Vila MB 

PROVIDER: S-EPMC12779756 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature