Harnessing early postoperative MRD and VAF dynamics for precision prognosis in resected colorectal liver metastases.

ABSTRACT:

Background

Circulating tumor DNA (ctDNA) shows promise for predicting recurrence in colorectal cancer liver metastases (CRLM) patients. We investigated the prognostic value of perioperative ctDNA, particularly 2 week postoperative minimal residual disease (MRD), in CRLM patients undergoing liver resection.

Methods

We prospectively collected blood samples from 94 CRLM patients before (after neoadjuvant therapy, if any) and 2 weeks after liver metastasectomy. 63 patients had both assessments. ctDNA status and variant allele fraction (VAF) were determined using targeted sequencing. Disease-free survival (DFS) was analyzed using Kaplan-Meier curves and Cox regression. Baseline characteristics were compared based on ctDNA status.

Results

Preoperative ctDNA status was not a

SUBMITTER: Li P 

PROVIDER: S-EPMC12779790 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature