Left atrial appendage occlusion vs standard of care in high stroke risk atrial fibrillation patients ineligible for anticoagulation: COMPARE-LAAO.

ABSTRACT:

Introduction

The left atrial appendage is the dominant source of cardioembolic stroke in patients with atrial fibrillation (AF). Contemporary guidelines recommend considering left atrial appendage occlusion (LAAO) in AF patients contraindicated to oral anticoagulation therapy (OAC), but randomized controlled trial (RCT) data for this subpopulation are lacking.

Methods

COMPARE LAAO was designed as an event-driven, multicenter, prospective, randomized, open, blinded endpoint (PROBE) trial that randomized AF patients with an increased thromboembolic risk and a contraindication to OAC 2:1 to LAAO or standard-of-care (SOC). The co-primary endpoints comprised 1) time to first occurrence of ischemic/hemorrhagic/undetermined stroke and 2) time to first occurrence of all-cause stroke

SUBMITTER: Aarnink EW 

PROVIDER: S-EPMC12779848 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature