The effect of dexmedetomidine on rocuronium-induced neuromuscular blockade and its reversal by sugammadex.

ABSTRACT:

Background

Dexmedetomidine (DEX) is increasingly used in the intensive care unit for sedation and also serves as an adjuvant in general anesthesia and in procedural sedations. We tested whether dexmedetomidine at different concentrations influences the activity of the neuromuscular junction at the diaphragm and whether DEX has an impact on the action of rocuronium at the diaphragm as well as the reversal of the neuromuscular block by sugammadex.

Methods

20 male Wistar rat phrenic nerve-hemidiaphragm system was used for our experiments. The concentration-response characteristics of DEX and rocuronium were quantified as the depression of the force amplitude of single twitches (ST) in response to electrical stimulation of the phrenic nerve. Rocuronium concentration-response cur

SUBMITTER: Fedor M 

PROVIDER: S-EPMC12779884 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature