Development and validation of a novel disulfidptosis-related gene signature for prediction of survival and immune microenvironment in osteosarcoma by WGCNA analysis.

ABSTRACT: Disulfidptosis was reported to be associated with the malignant progression of various tumors. This study was aimed to investigate the prognostic significance of disulfidptosis-related genes (DRGs) in osteosarcoma (OS). Ten previously reported core disulfidptosis genes were used for consensus clustering and WGCNA analyses. A total of 338 disulfidptosis-related genes (DRGs) were identified. Then, uni-COX, LASSO and multi-COX analyses were conducted, identifying 5 prognosis-related DRGs (BTN3A1, CEBPA, KCNAB2, TBX21, and MYC). A prognostic DRGs risk signature based on the five genes were constructed and validated. OS patients were divided into high and low risk groups by risk scores. K-M plots and t-ROC curves showed that patients with high-risk scores had worse prognosis. Patients in the hi

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC12779885 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature