Harnessing Ubiquitin-Proteasome System-Related Genes to Identify Subtypes of Bladder Cancer and Reveal Immune Landscape.

ABSTRACT: The ubiquitin-proteasome system (UPS) is intricately linked to the growth and metastasis of numerous types of cancer. However, current analysis on the function and impact of UPS in bladder cancer (BLCA) is still sparse. First, univariate Cox regression analysis was applied to screen survival-associated UPS-related genes (UPSGs). Then, based on the expression of survival-related UPSGs, BLCA patients were divided into three clusters through unsupervised cluster analysis, and the overall survival rate of Cluster 1 and Cluster 3 was higher than that of Cluster 2, but there was no survival difference between Cluster 1 and Cluster 3. Therefore, Cluster 1 + Cluster 3 (Cluster A) and Cluster 2 (Cluster B) were selected for subsequent analysis. The differentially expressed genes of the two clusters

SUBMITTER: Shi G 

PROVIDER: S-EPMC12779901 | biostudies-literature | 2026 Jan-Feb

REPOSITORIES: biostudies-literature