Frailty and its association with mental health and quality of life in multiple sclerosis: A cross-sectional study.

ABSTRACT:

Background

With the increasing median age of people with multiple sclerosis (MS), age-related syndromes such as frailty have emerged as new challenges to patient well-being. Prior research on frailty in MS has primarily focused on physical aspects, leaving the relationship between frailty and mental health unexplored.

Objective

To investigate the associations between frailty, mental health, and quality of life (QoL) in people with MS.

Design

Cross-sectional questionnaire-based study conducted at the Center for MS Care at the University of Kansas Medical Center.

Methods

Participants completed validated measures of frailty (Tilburg Frailty Indicator), anxiety and depression (Hospital Anxiety and Depression Scale), QoL (Multiple Sclerosis Quality of Life-54), and

SUBMITTER: Al Worikat N 

PROVIDER: S-EPMC12779911 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature