Diagnostic digital phenotyping in schizophrenia-spectrum disorders: a systematic review.

ABSTRACT: Digital phenotyping offers a promising but heterogeneous approach for assessing schizophrenia-spectrum disorders (SSD). This systematic review, the first of its kind, comprehensively analyzes the diagnostic and predictive utility of digital phenotyping in SSD. Following PRISMA guidelines, we synthesized data from 142 peer-reviewed studies (2004-2024; n = 6294 participants). Results show a predominance of smartphone and wearable-based approaches, with only ~20% of studies combining active and passive methods. Among six symptom domains, cognitive performance yielded the largest pooled effect size (Hedges' g ≈ 1.20) for differentiating individuals with SSD from controls, followed by behavior and activity (g ≈ 0.62). However, both domains exhibited very high heterogeneity (I² > 70%). Correlati

SUBMITTER: Vecchio I 

PROVIDER: S-EPMC12779945 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature