In vitro anti-inflammatory potential and in vivo anti-arthritis activities of Ximenia caffra extract on antigen-induced arthritis in rats.

ABSTRACT: The current study estimated the in vitro anti-inflammatory activity and in vivo anti-arthritic activities of the aqueous ethanolic extract of Ximenia caffra (X. caffra) seeds extract. It was hypothesized that X. caffra seeds extract, rich in phytochemicals that could modulate inflammatory pathways and protect joint tissues in an antigen-induced arthritis rat model. The chemical composition of X. caffra seeds extract was examined using liquid chromatography high-resolution mass spectrometry (LC-HRMS). Ximenia caffra seeds extract showed promising in vitro anti-inflammatory activity with an IC₅₀ = 26.01 ± 0.85 µg/ml. To evaluate in vivo efficacy, antigen-induced arthritis was established in rats using Complete Freund's Adjuvant (CFA), followed by subcutaneous administration of X.

SUBMITTER: Yosri M 

PROVIDER: S-EPMC12779950 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature