Peptide-functionalized membrane camouflage for endogenous H₂S-induced photothermal immunotherapy of orthotopic colorectal cancer.

ABSTRACT: The significant challenges pose by the high recurrence and metastasis rates of colorectal cancer (CRC) persist in its diagnosis and treatment. Activating innate immunity in CRC treatment has the potential to reduce drug resistance and side effects. Here, we develop a biomimetic platform by utilizing antimicrobial peptide-functionalized CRC cell membranes to encapsulate a cobalt-based metal-organic framework (C), hereby called peptide-functionalized camouflage C (PfCC). When injected into tumour-bearing mice, PfCC will degrade under the acidic condition of the tumour microenvironment and release cobalt ions, which react with endogenous H₂S to generate black stellate precipitates with good photothermal properties, recruiting NK cells and mitigates the immunosuppressive tumour-micr

SUBMITTER: Cheng K 

PROVIDER: S-EPMC12780019 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature