Multivariate fetal growth trajectory modeling and its association with maternal fatty acids.

ABSTRACT: Maternal circulating fatty acids are closely linked to fetal development. However, few studies have investigated the relationship between the maternal fatty acid levels at 11-14 weeks of gestation and fetal growth trajectories phenotype. A total of 655 pregnant women were selected from the Complex Lipids in Mothers and Babies cohort. Twenty fatty acids in maternal serum at 11-14 weeks of gestation were quantified by GC-MS. The trajectories of fetal head circumference (HC), biparietal diameter (BPD), abdominal circumference (AC), and femur length (FL) z-score at 11-14, 22-28, and 32-34 weeks of gestation were determined by group-based multi-trajectory modeling (GBMTM). Multinomial logistic regression and quantile-based g-computation (Qgcomp) were used to investigate the relationship between

SUBMITTER: Huang S 

PROVIDER: S-EPMC12780062 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature