Bone mechano-response is driven by locomotion transitions during vertebrate evolution.

ABSTRACT: The skeleton supports the muscles in keeping the body upright against gravity while enduring thousands of daily loads. In this study, we investigated non-collagenous bone matrix proteins using osteoblast cell cultures and phylogenetic analyses to identify the molecular mechanisms involved in mechanical loading. The results indicate that several non-collagenous proteins may significantly regulate the bone's response to mechanical stress. Furthermore, we hypothesize that the bone mechano-response is an evolutionary-driven process. The selection analysis indicates that two of the major evolutionary transitions in vertebrate locomotion shaped the roles of non-collagenous proteins in the bone matrix: the water-to-land transition, which increased mechanical stress on the limbs, and the evolution

SUBMITTER: Shimochi S 

PROVIDER: S-EPMC12780083 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature