Co-occurrence of mcr-1 and mcr-3 mobilized colistin resistance genes among carbapenem-resistant Pseudomonas aeruginosa in Iran.

ABSTRACT: Carbapenemase-producing Pseudomonas aeruginosa (CRPA) poses a significant challenge to the effectiveness of antimicrobial therapy in patients, further complicated by the emergence of colistin resistance (CLR). This study aimed to provide molecular epidemiological insights into clinical P. aeruginosa strains that produce carbapenemases and exhibit CLR. A total of fifty clinical isolates of CRPA were collected from Milad Hospital in Tehran, Iran. Antimicrobial susceptibility testing and colistin broth disk elution were performed to determine the resistance patterns. PCR assays were conducted to investigate the prevalence of resistance-associated genes, including bla_KPC, bla_IMP, bla_VIM, bla_OXA-48, bla_NDM, and mcr-1 to -10. Molecular typin

SUBMITTER: Davoodi NR 

PROVIDER: S-EPMC12780099 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature