Whole genome sequencing-based detection of extensively drug-resistant tuberculosis from Ethiopia.

ABSTRACT:

Background

Rapid and accurate detection of extensively drug-resistant tuberculosis is crucial for effective intervention. Next-generation sequencing technologies have been recommended to rapidly and accurately detect resistance to second-line anti-TB drugs. We deployed whole-genome sequencing to detect mutations associated with drug resistance in pre-extensively drug-resistant tuberculosis and extensively drug-resistant tuberculosis strains in Ethiopia.

Methods

This report is part of the routine laboratory-based drug-resistance surveillance in Ethiopia. Among 15 pre-extensively drug-resistant tuberculosis and extensively drug-resistant tuberculosis isolates identified during the study period, eleven isolates were retrieved by Whole-genome sequencing. Illumina NextSeq 550 ins

SUBMITTER: Diriba G 

PROVIDER: S-EPMC12780197 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature