Tailoring, spectroscopic, DFT, solvatochromic, antitumor, and molecular docking studies of new polynuclear Cu(II)-hydrazone complexes.

ABSTRACT: Hydrazones and their metal complexes have acquired a lot of interest because of their various biological and catalytic applications. The reaction of the symmetrical hydrazone (NBHD) with Cu(II) salts, including Cl^-, Br^-, and SO₄^2-, has been investigated. The structures of Cu-NBHD complexes were explored by using various spectroscopic and analytical tools. Fluorescence spectra for NBHD and Cu(II)-NBHD complexes were recorded in a large number of solvents to probe their solvatochromic manners. Theoretical calculations for NBHD and Cu-NBHD complexes were conducted, and the results were correlated with the experimental data. The anticancer action of Cu-NBHD complexes was investigated towards Hepatocellular carcinoma and the results were supported by

SUBMITTER: Samy F 

PROVIDER: S-EPMC12780247 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature