Inhalation & intravenous: umbilical cord mesenchymal stem cell-derived exosomes therapy strategy for acute respiratory distress syndrome in a murine model.

ABSTRACT:

Background

Acute respiratory distress syndrome (ARDS) is a complex syndrome characterized by acute diffuse lung injury and progressive respiratory failure, caused by various intra- and extra-pulmonary factors. The coronavirus disease 2019 (COVID-19) pandemic has significantly increased the incidence of ARDS, posing a tremendous threat to human health due to its high mortality rate and lack of effective therapeutic drugs. In recent years, mesenchymal stem cell-derived exosomes (MSC-exo) have been considered a new hope for the treatment of ARDS due to their potent immunomodulatory characteristics. Although multiple studies have demonstrated their efficacy and safety, the differential therapeutic effects of various administration routes and doses remain unclear. This study aimed to in

SUBMITTER: Yang L 

PROVIDER: S-EPMC12780377 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature