Mediastinal lymph node dissection in T1 stage lung adenocarcinoma: a retrospective analysis of survival outcomes and prognostic factors from the SEER database.

ABSTRACT:

Background

There is no consensus on whether a thorough mediastinal lymph node dissection (MLND) is necessary for stage I lung adenocarcinoma (AD) patients who require lobectomy. This study aimed to evaluate the survival impact of MLND in patients with T1 stage lung AD undergoing lobectomy.

Methods

We conducted a retrospective cohort study of 5,398 patients diagnosed with lung AD (tumor diameter 1-29 mm) from 2004 to 2015, utilizing data from the Surveillance, Epidemiology, and End Results (SEER) program. Patients were treated with either lobectomy only or lobectomy with MLND. The primary endpoint was overall survival (OS), analyzed using Kaplan-Meier survival analysis, Chi-squared testing, and Cox regression analysis.

Results

At a median follow-up of 97 months, the me

SUBMITTER: Wu B 

PROVIDER: S-EPMC12780382 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature