TRF-29-86J8WPMN1EJ3: a tRNA-derived small RNA promoting esophageal cancer progression.

ABSTRACT:

Background

Transfer RNA-derived small RNAs (tsRNAs) have been shown to participate in tumorigenesis and progression of human cancers. We aimed to identify dysregulated tsRNAs in esophageal cancer (EC) and uncover the underlying mechanisms.

Methods

tsRNA profiles for EC were downloaded from MINTbase. We also detected expression levels of tsRNAs in EC tissues using tsRNA sequencing and real-time quantitative polymerase chain reaction (RT-qPCR). The functional roles of tRF-29-86J8WPMN1EJ3 in EC were investigated by transfecting EC cell lines with mimics of tRF-29-86J8WPMN1EJ3 and assessing phenotypes through colony formation, wound healing, and Transwell assays.

Results

Totally, 210 differentially expressed tsRNAs were identified from MINTbase. In addition, 40 EC patient

SUBMITTER: Yu X 

PROVIDER: S-EPMC12780390 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature