Role of genetic alterations on outcomes for pulmonary resection in oligometastatic non-small cell lung cancer.

ABSTRACT:

Background

Local consolidative therapy (LCT) can improve survival outcomes for select patients with oligometastatic non-small cell lung cancer (NSCLC). While genetic alterations affect prognosis in NSCLC, their impact in oligometastatic patients undergoing lung resection as part of comprehensive LCT (cLCT) remains unclear. We sought to evaluate outcomes based on genetic alteration status in this population.

Methods

We identified oligometastatic (≤3 synchronous sites) NSCLC patients from 2 centers who underwent cLCT to all disease sites from 1996-2023. Patients were stratified by genetic alteration status. Survival outcomes were evaluated with Kaplan-Meier and multivariable Cox regression models.

Results

We identified 87 patients with the following genetic alterations:

SUBMITTER: Hooda Z 

PROVIDER: S-EPMC12780397 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature