An interpretative review of North American expert consensus on the clinical role of ex vivo lung perfusion (EVLP) with acellular perfusate.

ABSTRACT: This article provides a systematic analysis and commentary on the North American Expert Consensus regarding the clinical role of ex vivo lung perfusion (EVLP) using acellular perfusate. The consensus outlines key recommendations, including general statements on EVLP, criteria for donor lung selection, critical assessment parameters during perfusion, and a decision-making framework for transplantation. It emphasizes that current clinical practice relies heavily on small-scale, non-randomized, single-center studies, which often require substantial reliance on clinical judgment and institutional experience. As a result, the consensus calls for further, more rigorous research to establish evidence-based guidelines for EVLP-related decisions. By integrating the consensus recommendations with re

SUBMITTER: Chen WY 

PROVIDER: S-EPMC12780431 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature