Diagnostic value of pleural fluid neuron-specific enolase for malignant pleural effusion.

ABSTRACT:

Background

Neuron-specific enolase (NSE) in pleural fluid has been proposed as a promising diagnostic biomarker. However, existing studies on the diagnostic accuracy of NSE have reported inconsistent results. This study aimed to assess the accuracy of NSE in differentiating malignant pleural effusion (MPE) from benign pleural effusion (BPE) and investigate potential sources of heterogeneity in the diagnostic performance of NSE reported in previous studies.

Methods

We prospectively enrolled patients with undiagnosed pleural effusion from two centers in China (Hohhot and Changshu) and blindly measured their pleural fluid NSE level using an electrochemiluminescence assay. The diagnostic accuracy of NSE was assessed using a receiver operating characteristic (ROC) curve and decis

SUBMITTER: Lin X 

PROVIDER: S-EPMC12780435 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature