Comparison among stereotactic body radiation therapy, lobectomy, segmentectomy, and wedge resection for clinical stage I non-small cell lung cancer: a network meta-analysis.

ABSTRACT:

Background

Lung resections and stereotactic body radiation therapy (SBRT) are primary treatments for clinical stage I non-small cell lung cancer (NSCLC). The aim of this network meta-analysis is to compare the differences in effectiveness between SBRT and specific lung resections, including lobectomy, segmentectomy, and wedge resection for clinical stage I NSCLC.

Methods

PubMed, EMBASE, Cochrane Library, and the ClinicalTrials.gov registry were searched. Random-effects model was conducted to assess differences in survival outcomes and treatment-related complication incidence between SBRT and three specific lung resections (lobectomy, segmentectomy, wedge resection). Subgroup analyses were performed according to clinical stages, regions, and publication years.

Results

SUBMITTER: Zhang J 

PROVIDER: S-EPMC12780438 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature