A prospective randomized open-label trial of sirolimus versus paclitaxel-coated balloons for the side branch of <i>de novo</i> coronary bifurcation lesion.

ABSTRACT:

Background

Drug-coated balloons (DCBs) are commonly used in small coronary arteries. A recent trial reported similar outcomes between paclitaxel-coated balloons (PCBs) and sirolimus-coated balloons (SCBs) in side branch (SB) stenosis after stenting main branch (MB). This trial investigated whether SCBs and PCBs produce similar effects in de novo bifurcation lesions.

Methods

In this prospective, multicenter, randomized, non-inferiority clinical trial, patients with de novo non-left main coronary bifurcation lesions undergoing provisional stent of SB were randomly assigned in a 1:1 ratio to receive either SCBs or PCBs in SB. The primary efficacy endpoint was the percentage of target lesion stenosis (TLS) in the SB observed on angiogram 9 months after treatment. S

SUBMITTER: Gao Q 

PROVIDER: S-EPMC12780450 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature