Novel insights into diagnosis and management of hyperreactivity: a narrative review.

ABSTRACT:

Background and objective

Hyperreactivity (HR) refers to an exaggerated biological response to a given stimulus that is within the normal physiological range, resulting from a lowered activation threshold of the involved system or effector cells. It commonly occurs after surgery, lung transplantation, and coronavirus disease 2019 (COVID-19) infection but lacks a unified concept and systematic understanding. This review aims to elucidate the concept, mechanisms, and disease spectrum of HR as an independent clinical entity, systematically explore its roles in postoperative conditions, lung transplantation, and COVID-19, and develop a biomarker-based hierarchical management framework, thereby providing a new paradigm for its precise recognition and intervention.

Methods

We syste

SUBMITTER: Liu X 

PROVIDER: S-EPMC12780458 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature