Ultra-short cyclic peptide Cy _RL-QN15 acts as a TLR4 antagonist to expedite oral ulcer healing.

ABSTRACT: Oral ulcers (OUs) are among the most common lesions of the oral mucosa, typically associated with pain and burning sensations, and remain clinically challenging due to the scarcity of effective treatment options. Cy _RL-QN15, a novel ultra-short cyclic heptapeptide recently shown to promote skin repair, diabetic wound healing, and follicle neogenesis, was evaluated for its therapeutic potential in mucosal repair. Using a rat OU model and a primary oral epithelial cell inflammation model, Cy _RL-QN15 significantly accelerated wound closure through coordinated modulation of immune-epithelial crosstalk, including suppression of inflammatory cytokine release from macrophages and neutrophils, reduction of pro-inflammatory factor secretion by oral epithelial cells, and enhanc

SUBMITTER: Ru ZQ 

PROVIDER: S-EPMC12780494 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature