Epigenetic regulation and maternal-to-zygotic transition in dwarf surf clam ( <i>Mulinia lateralis</i>): Insights from chromatin state profiling and transcriptomics.

ABSTRACT: Bivalve mollusks represent a taxonomically and economically significant clade within Mollusca. However, the regulatory mechanisms governing their embryonic development remain poorly characterized. The dwarf surf clam ( Mulinia lateralis), characterized by a short generation time and high fecundity, has recently gained recognition as an ideal model system for bivalve embryological research. This study explored the epigenetic mechanisms driving embryogenesis in M. lateralis, with a particular focus on the maternal-to-zygotic transition (MZT), by integrating chromatin-state profiling and transcriptomic analysis. For the first time in this species, CUT&Tag was employed to generate high-resolution landscapes of histone modifications H3K4me1, H3K4me3, H3K27me3, and H3K27ac across k

SUBMITTER: Shi JL 

PROVIDER: S-EPMC12780502 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature