Amphibians as a source of bioactive antioxidant peptides: Emerging insights and therapeutic potential.

ABSTRACT: Oxidative stress arises from disruption of the balance between reactive oxygen species (ROS) production and detoxification and constitutes a fundamental driver of diverse pathological diseases. Skin photoaging is a well-recognized example, primarily driven by chronic ultraviolet (UV) exposure and marked by progressive structural and functional deterioration. UV-induced ROS accelerate macromolecular degradation and impair epidermal and dermal barrier integrity, highlighting the urgent need for effective antioxidant interventions. Antioxidant peptides (AOPs), whether naturally occurring or synthetically engineered, have shown considerable potential in mitigating ROS-induced cellular damage. Amphibians, which possess highly permeable skin and are continuously challenged by fluctuating environ

SUBMITTER: Zhu YY 

PROVIDER: S-EPMC12780510 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature