Glutaryl-CoA dehydrogenase: a key biomarker linking lysine degradation to hepatocellular carcinoma metastasis and prognosis via NF-KB signaling pathway.

ABSTRACT:

Background

Metastasis is the primary cause of mortality in patients with hepatocellular carcinoma (HCC). Metabolic reprogramming is a well-known hallmark of cancer metastasis. The aim of this study was to elucidate the role of metabolism in HCC metastasis.

Methods

Bulk RNA data were retrieved from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus databases (GEO). A combination of in vitro and in vivo experiments was conducted to evaluate the effects of glutaryl-CoA dehydrogenase (GCDH) on HCC progression. RNA sequencing was performed to investigate the underlying molecular mechanisms.

Results

Our findings revealed that lysine degradation pathway activity declined during HCC progression and metastasis. GCDH, a key regulator of the lysine degradation pathway, w

SUBMITTER: Hu Q 

PROVIDER: S-EPMC12780557 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature