Efficacy of coronary computed tomography angiography and its fractional flow reserve in predicting myocardial ischemia in patients with obstructive coronary artery disease with positron emission tomography myocardial perfusion imaging as a reference standard.

ABSTRACT:

Background

Coronary artery disease (CAD) remains one of the leading causes of mortality worldwide. Accurate assessment of myocardial ischemia is essential for guiding clinical management. This study aimed to evaluate and compare the diagnostic efficacy of coronary computed tomography angiography (CCTA) for the visual coronary analysis (VCA) of stenosis, quantitative coronary analysis (QCA), and computed tomography-derived fractional flow reserve (CT-FFR) for predicting myocardial ischemia in patients with obstructive CAD, with positron emission tomography (PET) myocardial perfusion imaging (MPI) serving a reference standard for myocardial ischemia.

Methods

Data on suspected or confirmed obstructive CAD cases with PET-MPI and concurrent CCTA were retrospectively collected. Th

SUBMITTER: Wang T 

PROVIDER: S-EPMC12780573 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature