Assessment of treatment efficacy for codeine-containing cough syrup dependence using single-photon emission computed tomography.

ABSTRACT:

Background

Codeine-containing cough syrup (CCS) misuse has become a growing global concern, particularly among young people, due to its potential for dependence. This study aimed to evaluate the efficacy of a comprehensive treatment approach for patients with dependence on CCS and to assess treatment outcomes through single-photon emission computed tomography (SPECT).

Methods

This study included 29 patients with CCS dependence and 31 matched controls. SPECT imaging was performed using the radiopharmaceutical agent ^99mTc-TRODAT-1. Patients with CCS dependence underwent comprehensive treatment, and SPECT examinations were conducted both before and after the intervention. Dopamine transporter (DAT) availability in the striatum was measured, and the volume (V), weight

SUBMITTER: Zhao ZQ 

PROVIDER: S-EPMC12780587 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature