Glymphatic system dysfunction in pediatric growth hormone deficiency evidenced by multiple MRI metrics.

ABSTRACT:

Background

The clearance of brain metabolic waste occurs mainly through the glymphatic system. This study aimed to explore the change of glymphatic function in children with growth hormone deficiency (GHD) using non-invasive imaging methods.

Methods

This prospective research recruited 40 cases of pediatric GHD and 40 age- and gender-matched typically developing (TD) children. Glymphatic circulation, which includes the production of cerebrospinal fluid (CSF), represented by choroid plexus volume (CPV), influx, evaluated by perivascular space (PVS) burden, and waste clearance, as indirectly assessed by diffusion tensor imaging-based analysis along the perivascular space (DTI-ALPS), was explored for all participants. Partial correlations were conducted between significant magne

SUBMITTER: Huang S 

PROVIDER: S-EPMC12780612 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature