Prospects for clinical translation of histotripsy in liver applications: a systematic review based on preclinical studies.

ABSTRACT:

Background

Histotripsy, an ablation method relying on acoustic cavitation, is characterized by its non-thermal, non-ionizing, and non-invasive properties. It has the advantages of tissue selectivity, real-time visualization, and precise ablation. Among the clinical applications of histotripsy, its use in the treatment of liver cancer is the most promising. This review aimed to synthesize preclinical evidence and provide a comprehensive evaluation of histotripsy in the treatment of liver disease.

Methods

PubMed, Embase, and Cochrane Library were searched from database inception to October 15, 2024 to retrieve relevant articles. The Systematic Review Centre for Laboratory Animal Experimentation risk of bias tool was used to assess study quality, and RevMan 5.4 was used to cond

SUBMITTER: Yu Y 

PROVIDER: S-EPMC12780615 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature