Quantitative ^99mTc-MDP SPECT/CT for predicting neoadjuvant chemotherapy efficacy in osteosarcoma.

ABSTRACT:

Background

Osteosarcoma (OS) is one of the most common primary malignant bone tumors. At present, research on the value of quantitative ^99mTechnetium-methylene diphosphonate single photon emission computed tomography/computed tomography (^99mTc-MDP SPECT/CT) for predicting neoadjuvant chemotherapy (NACT) efficacy in OS is limited. The purpose of this study was to assess the predictive value of quantitative ^99mTc-MDP SPECT/CT in predicting NACT efficacy in OS.

Methods

This retrospective study collected ^99mTc-MDP bone scans and quantitative ^99mTc-MDP SPECT/CT data of all OS patients from February 2019 to February 2025 at Beijing Jishuitan Hospital, Capital Medical University. The NACT efficacy was assessed based on postoper

SUBMITTER: Wang C 

PROVIDER: S-EPMC12780616 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature