The "long-tongue" sign: a new perspective on magnetic resonance imaging images of medullary ganglioglioma.

ABSTRACT: Medullary ganglioglioma (GG) is an exceptionally rare tumor of the central nervous system, and its early diagnostic markers and prognostic indicators remain poorly defined. In this multi-center retrospective study, we reviewed 13 cases of histopathologically confirmed medullary GG to investigate their magnetic resonance imaging characteristics and assess the potential correlation between imaging features and BRAF V600E mutation status. A novel imaging feature-termed the "long-tongue" sign-was identified, characterized by patchy enhancement along the dorsal aspect of the medulla on contrast-enhanced T1-weighted imaging. This feature was observed in 11 out of 13 patients (84.6%). Among the 8 cases with available molecular data, 7 (87.5%) tested positive for the BRAF V600E mutat

SUBMITTER: Wu S 

PROVIDER: S-EPMC12780637 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature