Histogram analysis based on contrast-enhanced T1-weighted imaging in pituitary macroadenomas: relation to histological subtype and expression.

ABSTRACT:

Background

Non-gonadotroph macroadenomas may exhibit higher cavernous sinus invasiveness compared to gonadotroph macroadenomas. Magnetic resonance imaging (MRI) is the preferred modality for detecting pituitary adenomas, yet, conventional MRI cannot distinguish gonadotroph from non-gonadotroph macroadenomas. This study aimed to evaluate the efficacy of histogram analysis based on contrast-enhanced T1-weighted imaging (CE-T1WI) for differentiating gonadotroph from non-gonadotroph macroadenomas.

Methods

A retrospective analysis was conducted on 58 gonadotroph and 60 non-gonadotroph macroadenomas, pathologically confirmed at Henan Provincial People's Hospital between January 2022 and September 2024. Using 3D Slicer software, regions of interest (ROIs) were delineated on the cor

SUBMITTER: Han Y 

PROVIDER: S-EPMC12780663 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature