Dynamic contrast-enhanced magnetic resonance imaging of the synovium and synovial subregions in knee osteoarthritis: test-retest repeatability.

ABSTRACT:

Background

Quantitative dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) can potentially be used to assess synovial inflammation in patients with knee osteoarthritis (OA). Precise methods are needed for adequate identification of changes in clinical trials. In this study, we aimed to evaluate test-retest repeatability of DCE-MRI within the synovium of patients with knee OA, and develop a semi-automatic method for synovial subregion assessment.

Methods

In this secondary explorative analysis, we included 31 adults with radiographically confirmed mild to moderate knee OA receiving sham treatment as participants of a randomized controlled trial evaluating genicular artery embolization. DCE-MRI of the knee was performed at baseline and at 1-month follow-up. The syno

SUBMITTER: Mostert JM 

PROVIDER: S-EPMC12780673 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature