Semiquantitative HRCT scoring: a reliable predictor of rapidly progressive interstitial lung disease in patients with anti-MDA5 positive dermatomyositis.

ABSTRACT:

Background

Anti-melanoma differentiation-associated gene 5 positive dermatomyositis (anti-MDA5 DM) is strongly linked to rapidly progressive interstitial lung disease (RP-ILD), which is associated with high early mortality. This study aimed to explore the feasibility of using semiquantitative visual scoring methods on high-resolution computed tomography (HRCT) to assess RP-ILD in anti-MDA5 DM patients, and to develop a risk prediction model for RP-ILD, given the poor prognosis of RP-ILD in anti-MDA5 DM.

Methods

The data of patients with anti-MDA5 DM were retrospectively analyzed. Seven HRCT-based semiquantitative scoring methods were used to assess the extent of interstitial lung disease (ILD), and the correlation of each method with the pulmonary function tests (PFTs) was a

SUBMITTER: Zhang C 

PROVIDER: S-EPMC12780674 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature