Amide proton transfer-weighted imaging in predicting aggressiveness of hepatocellular carcinoma: comparison with diffusion-weighted imaging.

ABSTRACT:

Background

Amide proton transfer-weighted (APTw) imaging provides molecular-level information for comprehensive tumor characterization, aiding in diagnosis, grading, and treatment response monitoring. The study aimed to investigate the potential of APT imaging in simultaneously predicting three key markers of hepatocellular carcinoma (HCC) aggressiveness-microvascular invasion (MVI), Ki-67 labeling index (LI) and histologic grade-and compare its performance to that of diffusion-weighted imaging (DWI).

Methods

Fifty-six patients with histologically confirmed HCC underwent abdominal magnetic resonance imaging (MRI) including APTw and DWI. Tumor mean APTw and apparent diffusion coefficient (ADC) values were measured and correlated with Ki-67 LI. The differences of APTw and ADC

SUBMITTER: Huang J 

PROVIDER: S-EPMC12780681 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature