A novel computed tomography-based algorithm for the quantitative identification of lumbar spine-localized trabecular bone loss in patients with type 2 diabetes mellitus.

ABSTRACT:

Background

Conventional bone health assessment based on average bone mineral density (BMD) cannot capture localized trabecular abnormalities, and BMD is not always decreased in patients with type 2 diabetes mellitus (T2DM). To overcome these limitations of using BMD alone in diagnosis, this study aimed to apply a novel computed tomography (CT)-based algorithm to quantitatively evaluate lumbar spine-localized trabecular bone loss (LTBL) in individuals with and without T2DM.

Methods

This study retrospectively enrolled individuals with and without T2DM, and their basic clinical information was collected. Lumbar spine BMD was measured via quantitative CT (QCT). LTBL was quantified via a novel algorithm, with LTBL defined as trabecular regions with BMD <40 mg/cm³ and v

SUBMITTER: Chen J 

PROVIDER: S-EPMC12780715 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature