Biopsy-proven tyrosine kinase inhibitor-associated renal injury: a case series.

ABSTRACT:

Background

Tyrosine kinase inhibitors (TKIs) are essential anticancer agents associated with substantial nephrotoxic potential. Although TKI-induced renal injury is increasingly recognized, comprehensive histopathological characterization remains limited due to insufficient renal biopsy data. This study characterizes the clinicopathological spectrum and outcomes of biopsy-proven TKI nephrotoxicity.

Methods

This retrospective study analyzed 21 patients with biopsy-proven TKI-associated renal injury identified between 2015 and 2025. Demographic characteristics, renal function indices, oncological profiles and histopathological features were analyzed.

Results

The cohort included 16 patients with solid tumors and 5 with hematologic malignancies exposed to four major TKI c

SUBMITTER: Lian J 

PROVIDER: S-EPMC12780777 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature