Disrupted astrocyte-neuron glutamine-glutamate cycling in the medial prefrontal cortex contributes to depression-like behaviors.

ABSTRACT: The regulation of the homeostasis of the glutamate (Glu)-glutamine (Gln) cycle within the medial prefrontal cortex (mPFC) has garnered substantial interest due to its essential role in maintaining normal emotional behaviors. Chronic stress possesses the potential to disrupt the homeostasis of the Glu-Gln cycle, thereby facilitating the onset of depressive behaviors. Nevertheless, the specific roles of individual components within the Glu-Gln cycle in relation to depression-related behaviors remain incompletely understood. This study aims to elucidate the specific roles of each component by implementing a cell- and region-specific conditional knockout (cKO) strategy. To achieve this goal, the genes encoding glutamine synthetase (GS), glutamate transporter 1 (GLT-1), and sodium-coupled neutr

SUBMITTER: Kang JS 

PROVIDER: S-EPMC12780845 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature