Neurological Manifestations and High Viral Load as Independent Predictors of Mortality in Severe Fever With Thrombocytopenia Syndrome.

ABSTRACT:

Background

Severe fever with thrombocytopenia syndrome (SFTS), an emerging tick-borne viral hemorrhagic fever, is characterized by high mortality rates. While neurological complications (eg, seizures, encephalitis) have been identified as adverse prognostic factors in severe cases, their association with viral replication, immune responses, and neuroinflammation remain poorly defined and urgently require systematic investigation.

Method

A cohort of 277 patients with SFTS was included and stratified based on neurological symptoms. Clinical characteristics, laboratory results, and immune markers were compared between groups.

Results

Neurological symptoms developed in 78 (28.2%) patients and were associated with significantly higher 28-day mortality. These patients had h

SUBMITTER: Chen R 

PROVIDER: S-EPMC12780883 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature