Validation of the Leuven Postprandial Distress Scale According to the Rome IV Criteria for Functional Dyspepsia.

ABSTRACT:

Background/aims

: The Leuven Postprandial Distress Scale (LPDS) is a validated patient reported outcome (PRO) measure for functional dyspepsia (FD)/postprandial distress syndrome (PDS) patients according to Rome III criteria. However, meal-related nausea or epigastric pain, part of PDS in Rome IV, were not addressed in this construct. Also, focus groups identified fatigue as a frequently reported complaint for which the European Medicines Agency requested further analysis. Our aim is to validate the LPDS in FD/PDS as defined by Rome IV criteria and to optimize the model by assessing the value of adding extra items to this questionnaire.

Methods

: The questionnaire was validated in 3 different Rome IV FD/PDS patient cohorts recruited for controlled clinical trials. Additional

SUBMITTER: Van de Bruaene C 

PROVIDER: S-EPMC12780899 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature