Donor-Recipient Age Mismatch and Long-Term Graft Outcomes After Adolescent Liver Transplant.

ABSTRACT:

Importance

Donor-recipient age mismatch is an established risk factor in adult liver transplants (LTs), yet its effect in adolescents, who require long-term graft durability, has not been fully characterized. Despite pediatric prioritization, some adolescent donor livers are allocated to adults, limiting access to age-matched grafts for adolescents.

Objective

To assess whether a donor-recipient age difference of 10 or more years is associated with inferior graft survival in LTs among adolescents and to estimate the benefits of broader geographic sharing of adolescent donor livers.

Design, setting, and participants

This retrospective, registry-based case-control study used data from the Organ Procurement & Transplantation Network database, a nationwide US transplant re

SUBMITTER: Nakayama T 

PROVIDER: S-EPMC12780930 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature