Characterization of monogenic diabetes among Sudanese children: a multi-center experience from a population with high consanguinity.

ABSTRACT:

Objectives

Monogenic diabetes (MD) is a group of diabetes subtypes caused by defects in single genes. We report phenotypes and genotypes of MD among Sudanese children.

Methods

Referred patients (from birth to 18 years of age) with diabetes and a clinical diagnosis of MD to Gaafar Ibnauf Pediatric Tertiary Hospital or the Sudan Childhood Diabetes Center between January 2006 and April 2023 were included. Patients were divided into two groups based on onset of diabetes before six months of age (Group 1, or neonatal diabetes mellitus) or after (Group 2, or non-neonatal diabetes mellitus). Genetic testing was performed for 87 patients at the Exeter Genomics laboratory and for one patient at the University of Cambridge, Metabolic Research Laboratories, UK.

Results

Out of 88

SUBMITTER: Hassan SS 

PROVIDER: S-EPMC12780942 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature