Prenatal Adversities and Risk of Persistent Youth Psychopathology and Altered Cortical Thinning.

ABSTRACT:

Importance

Adverse prenatal exposures (APEs) often co-occur and independently associate with risk for childhood psychopathology. Whether exposure to multiple APEs is associated with persistent clinical effects through adolescence or underlying changes in brain maturation remains uncertain.

Objective

To evaluate longitudinal associations among cumulative APE burden, risk for psychopathology, and age-related cortical thinning in adolescents.

Design, setting, and participants

This cohort study analyzed 4-year follow-up data from the Adolescent Brain Cognitive Development (ABCD) Study, which enrolled 11 868 youth aged 9 to 10 years beginning in 2016. Sibling-comparison analysis was performed on 414 nonadopted sibling pairs with discordant APEs. Statistical analysis occurr

SUBMITTER: Zhi D 

PROVIDER: S-EPMC12780982 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature