Genomic Insights Into the Treponema Genus: Taxonomic Resolution of Treponema vincentii and Description of Two Novel Species, Treponema plautii sp. nov. and Treponema sinense sp. nov.

ABSTRACT:

Objectives

Periodontal disease, a global health concern, is strongly associated with oral treponemes. However, the taxonomy of some species remains unresolved, hindering our understanding of their roles in disease. This study aims to clarify the taxonomy of three strains isolated from patients with periodontal disease using phylogenomic and comparative genomic analyses.

Materials and methods

We performed genome sequencing for OMZ 800 and conducted phylogenomic and comparative genomic analyses of multiple strains to clarify their taxonomy.

Results

Phylogenomic and in-silico genome comparisons confirmed OMZ 800 as "T. vincentii" (Average Nucleotide Identity [ANI]>95%). We designated OMZ 800^T as the type strain for T. vincentii to establish its official standi

SUBMITTER: Fong JYH 

PROVIDER: S-EPMC12781046 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature