A Multifunctional Nanoplatform for Treating Hepatic Ischemia-Reperfusion Injury by Modulating the Nrf2 and NF-κB Pathways.

ABSTRACT: Hepatic ischemia-reperfusion injury (HIRI), a critical pathological process in surgeries such as liver transplantation and hepatectomy, involves complex mechanisms, including oxidative stress, immune-inflammatory responses, and cell apoptosis. However, universally accepted clinical treatment remains lacking. In this study, an erythrocyte-membrane-coated poly(lactic-co-glycolic acid) (PLGA) nanoplatform was constructed to deliver edaravone (Eda) and dexamethasone (Dex), ingeniously transforming the physiological clearance of nanoparticles by the hepatic reticuloendothelial system into a targeted delivery strategy. Edaravone synergizes with the nuclear factor E2-related factor 2 (Nrf2) pathway to scavenge excessive reactive oxygen species (ROS) in damaged hepatocytes, reducing the lev

SUBMITTER: Shuai L 

PROVIDER: S-EPMC12781059 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature