Bioactive Limonene-Derived Oligomer in Gelatin Hydrogels: Impact of Cross-Linking Chemistry on Physicochemical Properties and Wound Healing Performance.

ABSTRACT: Antioxidant photo-cross-linkable hydrogels have garnered significant interest for biomedical applications, but challenges such as additive thermal instability and interference with cross-linking remain. Here, we report the first systematic comparison of a limonene-derived oligomer (PLM) incorporated into two distinct photo-cross-linkable gelatin platforms, highlighting how cross-linking chemistry governs antioxidant performance and network integrity. PLM was incorporated at 5% and 10% (w/w, relative to gelatin), comparing the performance of gelatin-methacryloyl (GelMA) and gelatin-norbornene (GelNB) hydrogels in terms of cross-linking efficiency, antioxidant retention, release profile, and biocompatibility upon PLM incorporation. While PLM negatively affected the physicochemical properties

SUBMITTER: Vieira RP 

PROVIDER: S-EPMC12781062 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature