DCBLD1 Promotes Lung Tumorigenesis by Inhibiting PTP1B Dephosphorylation of EGFR.

ABSTRACT: Lung adenocarcinoma (LUAD) progression involves multistep molecular pathogenesis, with many critical mediators of malignant transformation yet to be fully characterized. Building upon our previous discovery of discoidin, CUB and LCCL domain containing 1 (DCBLD1) as a novel LUAD risk-associated gene, we systematically investigated its function and underlying mechanisms in LUAD. Intriguingly, DCBLD1 overexpression promotes cellular transformation in both bronchial epithelial cells and EGFR^L858R alveolar type II organoids, while its deficiency in DCBLD1^-/- mice significantly suppresses LUAD initiation. Mechanistic studies revealed that DCBLD1 drives oncogenesis through direct interaction with EGFR. Specifically, the intracellular domain of DCBLD1 competitively binds to E

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12781078 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature